Martha B. Furie, PhD, Professor

 

 

 

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    Martha B. Furie, PhD
    Professor of Pathology
    Professor of Molecular Genetics and Microbiology
    Director, Graduate Program in Genetics
    Room 248, Centers for Molecular Medicine

    Stony Brook University
    Stony Brook, NY 11794-5120

    Tel: (631) 632-423
    Fax: (631) 632-4294
    Email: 
    Martha.Furie@stonybrook.edu

    Research Summary:

    The Furie Laboratory has a broad interest in how the body’s innate immune system interacts with bacterial pathogens, including Borrelia burgdorferi (the agent of Lyme disease) and Francisella tularensis (the cause of tularemia).  A particular focus is on recruitment of circulating leukocytes to infected tissues.  This recruitment is controlled by the endothelial cells that line the blood vessels.  When activated, endothelial cells express adhesion molecules and secrete attractants that direct the movement of the white cells from the blood into infected tissues.  These leukocytes play an essential role in host defense, but their anti-microbial weaponry can also injure healthy tissues if unleashed inappropriately or excessively.  Using in vitro and in vivo approaches, we have dissected the mechanisms whereby B. burgdorferi and F. tularensis regulate recruitment of leukocytes.  Another area of major interest is interactions of F. tularensis with hepatocytes, the main cells of the liver.  F. tularensis grows within hepatocytes, and we aim to understand how the bacteria and the host cells mutually adapt and respond to the intracellular infection.

    Education:   

    Institution and LocationDegreeYear(s)Field of Study
    Cornell University, Ithaca, NY  
    B.S.
    1974Genetics
    The Rockefeller University, New York, NYPh.D.
    1980Protein Chemistry

    Positions and Employment:

    1980-84Postdoctoral Fellow, The Rockefeller University
    1980-86Associate Research Scientist, Columbia University
    1986-92Assistant Professor of Pathology, Stony Brook University
    1992-00Associate Professor of Pathology, Stony Brook University
    1992-presentGraduate Program Faculty in Molecular and Cellular Biology
    2000-presentProfessor of Pathology, Stony Brook University
    2000-presentGraduate Program Faculty in Molecular Genetics and Microbiology
    2003-presentGraduate Program Faculty in Genetics
    2005-presentProfessor of Molecular Genetics and Microbiology, Stony Brook University
    2009-presentSchool of Medicine Appointments, Promotion, and Tenure Committee
    2013-presentUniversity Graduate Council
    2014-present
    Director, Graduate Program in Genetics

    Other Experience and Professional Memberships (selected):

    1992-present   
    American Society for Investigative Pathology
    1993-08Editorial Board, The American Journal of Pathology
    2004-06Program Chair, Annual Meeting of the American Society for Investigative Pathology
    2006-09Chair, Education Committee, American Society for Investigative Pathology
    2006-presentCouncil Member, American Society for Investigative Pathology
    2007-presentAmerican Society for Microbiology
    2008-12Associate Editor, The American Journal of Pathology
    2011-12President, American Society for Investigative Pathology
    2013-presentSenior Associate Editor, The American Journal of Pathology

    Honors (selected):

    1974                             
    BS with honors and distinction
    1974-77                 
    National Science Foundation Predoctoral Fellowship
    1980-81   Damon Runyon-Walter Winchell Cancer Fund Postdoctoral Fellowship
    1981-84 National Cancer Institute Postdoctoral Fellowship
    1985-86Investigatorship, New York Heart Association
    1987-90Aaron Diamond Foundation Scholar
    1988-91Alexandrine and Alexander L. Sinsheimer Fund Scholar