PhD, University of Pennsylvania
Centers for Molecular Medicine (CMM)
Office: Room 334
Lab: Room 335
Gary Matthews was educated at the University of California at San Diego (B.A., 1971) and the University of Pennsylvania (Ph.D., 1975). He was Research Associate in the Department of Physiology at the University of Colorado Medical School from 1975 to 1978, and from 1978 to 1981 he was Postdoctoral Fellow in the Department of Neurobiology at Stanford University School of Medicine. In 1981 he joined the Department of Neurobiology and Behavior at Stony Brook University, where he currently holds the title of Leading Professor. Professor Matthews is a member of the Center for Nervous System Disorders and the Multiple Sclerosis Collaborative Research Center at Stony Brook University. He currently serves on the Editorial Board of the Journal of Neurophysiology, and has served on the editorial board of the Biophysical Journal and as associate editor of the Journal of Neuroscience. He was awarded fellowships from the Sloan, von Humboldt, Woodrow Wilson, Ford, and Guggenheim foundations, and has received the von Humboldt Award (1994), Brian Boycott Prize (2008), and Sir Bernard Katz Award (2009). Professor Matthews is a member of the American Physiological Society, the Biophysical Society, the Association for Research in Vision and Ophthalmology, and the Society for Neuroscience.
Research Interests/ExpertiseThe research in my laboratory is concerned with how neurons communicate. One focus of our work is the synaptic vesicle cycle, the process of exocytosis and endocytosis that mediates chemical neurotransmission. To study the regulation of synaptic exocytosis and endocytosis, we use electrophysiological assays, such as capacitance measurements, together with a variety of imaging techniques, including calcium imaging, confocal microscopy, evanescent field microscopy, and electron microscopy.
- Laboratory Personnel
- Snellman J, Mehta B, Babai N, Bartoletti TM, Akmentin W, Francis A, Matthews G, Thoreson W, Zenisek D. (2011) Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming. Nature Neuroscience, doi: 10.1038/nn.2870. [Epub ahead of print] [PMID]
- Matthews G, Fuchs P. (2010) The diverse roles of ribbon synapses in sensory neurotransmission. Nature Reviews Neuroscience, 11, 812-822. [PMID]
- Zanazzi G, Matthews G. (2010) Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development. Neural Dev. 2010 5,24. [PMID]
- Logiudice L, Sterling P, Matthews G. (2009) Vesicle recycling at ribbon synapses in the finely branched axon terminals of mouse retinal bipolar neurons. Neuroscience. 164, 1546-1556. [PMID]
- Zanazzi G, Matthews G. (2009) The molecular architecture of ribbon presynaptic terminals. Mol Neurobiol. 39(2):130-48. [PMID]
- LoGiudice L, Matthews G. (2009) The role of ribbons at sensory synapses. Neuroscientist. 15, 380-391. [PMID]
- Matthews, G. and Sterling, P. (2008) Evidence That Vesicles Undergo Compound Fusion on the Synaptic Ribbon. Journal of Neuroscience, 28, 5403-5411. [PMID]. Article featured in "This Week in The Journal."
- LoGiudice, L, Sterling, P, and Matthews, G. (2008) Mobility and turnover of vesicles at the synaptic ribbon. Journal of Neuroscience, 28, 3150-3158. [PMID]
- Goldfarb, M., Schoorlemmer, J., Williams, A., Diwakar, S., Wang, Q., Huang, X., Giza, J., Tchetchik, D., Kelley, K., Vega, A., Matthews, G., Rossi, P., Ornitz, D.M., and D'Angelo, E. (2007) Fibroblast growth gactor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron, 55, 449-463. [PMID]
- LoGiudice, L. and Matthews, G. (2007) Endocytosis at ribbon synapses. Traffic, 8, 1123-1128. [PMID]
- Van Wart, A., Trimmer, J.S., and Matthews, G. (2007) Polarized distribution of ion channels within microdomains of the axon initial segment. Journal of Comparative Neurology, 500, 339-352. [PMID]
- Van Wart, A., and Matthews, G. (2006) Impaired firing and cell-specific compensation in neurons lacking Nav1.6 sodium channels. Journal of Neuroscience, 26, 7172-7180. [Cover picture] [PMID]
- Wendy Akmentin - Research Technician
- Diane Henry-Vanisko - Research Technician
- Thirumalini Vaithianathan - Postdoctoral Associate
- Karen Wexler - Research Technician