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Joint appointment in Physiology and Biophysics
Phone: (631) 444-3458
Research webpage
Lab webpage

  • 1974-79 Stony Brook University. Ph.D. Physics/Biophysics
  • 1980-82 University of Cambridge, Cambridge, UK. Postdoc in Physiology
  • 1982-84 Stony Brook University. Postdoc in Neurobiology

Research Interests:
  • Mechanisms of anesthetic action
  • Ligand gated ion channel kinetics
  • TRPM7 channels

Selected Publications:
  • PubMed Search
  • Barann M, Dilger JP, Bönisch H, Göthert M, Dybek A, Urban BW. Inhibition of 5-HT3 receptors by propofol: Equilibrium and kinetic measurements. Neuropharmacology. 39:1064-1074, 2000. PMID: 10727717
  • Eger EI, Fisher DM, Dilger JP, Sonner JM, Evers A,  Franks NP, Harris RA,  Kendig JJ, Leib WR, Yamakura T. Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology 94:915-921, 2001. PMID: 11388545
  • Spitzmaul G, Dilger JP, Bouzat C. The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors.. Mol Pharmacol 60:235-243, 2001.  PMID: 11455009
  • Wenningmann I, Barann M, Vidal AM, Dilger JP. The effects of isoflurane on acetylcholine receptor channels: 3. Effects of conservative polar-to-nonpolar mutations within the channel pore. Mol Pharmacol 60:584-594, 2001.  PMID: 11502891
  • Wenningmann I, Dilger JP. The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.. Mol Pharmacol 60:790-796, 2001.  PMID: 11562442
  • Demazumder D, Dilger JP. The kinetics of competitive antagonism by cis-atracurium of embryonic and adult nicotinic acetylcholine receptors. Mol Pharmacol. 60:797-807, 2001.  PMID: 11562443
  • Dilger JP. The effects of general anaesthetics on ligand-gated ion channels. Br. J. Anaesth. 2002 89: 41-51.  PMID: 12173240
  • Dilger JP, Vidal AM, Liu M, Mettewie C, Suzuki T, Pham A, Demazumder D. Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists. Anesthesiology. 2007 Jun;106(6):1186-1195 PMID: 17525594
  • Liu M, Dilger JP. Synergy between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors. Anesth Analg 2008 Aug;107(2):525-33 PMID: 18633030
  • Demazumder D, Dilger JP. The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature. J Physiol 2008 586:951-63 PMID: 18063662
  • Spitzmaul G, Gumilar F, Dilger JP, Bouzat C. The Local Anesthetics Proadifen and Adiphenine Inhibit Nicotinic Receptors by Different Molecular Mechanisms. Br J Pharmacol. 2009 Jul;157(5):804-17. PMID: 19422391
  • Liu M, Dilger JP. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Mol Pharmacol. 2009 Jan;75(1):166-73. PMID: 18842832
  • Dilger JP. Monte Carlo simulation of buffered diffusion into and out of a model synapse. Biophys J. 2010 Mar 17;98(6):959-967 PMID: 20303853
  • Dilger JP. Simulation of the kinetics of neuromuscular block: Implications for speed of onset. Anesth Analg. 2013 Oct;117(4):792-802. PMID: 23456666

Recent Presentations:
  • Khan N, Zheng G, Dilger JP. Volatile anesthetics suppress desensitization of a1 and a1b glycine receptor currents. 9th International Conference on Mechanisms of Anesthesia, June 2015
  • Groeneveld K, Dilger JP, Urban BW. Single channel characterization of human 5-HT3A QDA receptors. 9th International Conference on Mechanisms of Anesthesia, June 2015