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Sandeep Mallipattu, MD
|Our research program focuses on identifying mechanisms involved in the progression of chronic kidney disease. Specifically, we investigate the mechanisms that regulate proliferation and differentiation of epithelial cells in the kidney.
We have found evidence that a highly specialized family of transcription factors, Krüppel-Like Factors (KLFs), are critically involved in regulating fundamental cellular processes in the kidney. We are currently using novel in vitro and in vivo approaches to establish the physiological and pathophysiological functions of KLFs in various disease processes (Diabetic Nephropathy, Focal Segmental Glomerulosclerosis, acute kidney injury transition to renal fibrosis); as well as high-throughput screening strategies to identify small molecular compounds that might serve as novel therapeutic agents in disease based on their ability to modulate the expression and function of KLFs.
These studies are currently supported with extramural funding from NIH/NIDDK, American Heart Association, Veterans Affairs, and Dialysis Clinic Inc. At Stony Brook Medicine, we continue many of these exciting studies and welcome any collaborative efforts.