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Achievements 2016 - 2017

Grants, Fellowships, and Awards

Bridges, R. (2016). SBU Sigma Xi Travel Award.

Bridges, R. (2016).Outstanding Poster Award,  Department of Molecular Genetics and Microbiology Annual Retreat.

Bryan, A. (2016). Teresa Haire Award, Department of Molecular Genetics and Microbiology.

Burton, E. (2016) Third Place Oral Presentation Award. 17th International Symposium on Epstein-Barr Virus and Associated Diseases. August 8-12, Zurich, Switzerland.

Chung, L. (2016). Abrahams Award for Outstanding Achievement by a Graduate Student.

Kopping, E. (2017). Ruth L. Kirschstein National Research Service Award for Individual Predoctoral Fellows (F31). National Institutes of Allergy and Infectious Diseases.

Kopping, E. (2016). Distinguished Travel Award. Stony Brook University Graduate Student Organization.

Kopping, E. (2016). Distinguished Service Award, Department of Molecular Genetics and MIcrobiology.

Orner, E. (2017). Young Investigator Award, 10th International Conference on Cryptococcus and Cryptococcosis. March 26-30, Foz do Iguacu, Brazil.

Zhang, S. (2016). Outstanding Poster Award, Department of Molecular Genetics and Microbiology Annual Retreat.


Jointly Authored Publications/Research Reports/Reviews

Bhagwat, A.S., Roe, J.S., Mok, B.Y., Hohmann, A.F., Shi, J., and Vakoc, C.R. 2016. BET bromodomain inhibition releases the mediator complex from select cis-regulatory elements. Cell Reports 15(3): 519-530.

Bouklas, T., Alonso-Crisostomo, L. Szekely, T. Jr., Diago-Navarro, E., Orner, E.P., Smith, K., Munshi M.A., Del Poeta, M., Balazsi, G., and Fries, B.C. (2017). Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host. PLoS Pathogens 13(5): e1006355.

Bridges, R.G., Sohn, S.Y., Wright, J., Leppard, K.N., and Hearing, P. 2016. The adenovirus E4-ORF3 protein stimulates SUMOylation of general transcription factor TFII-I to direct proteasomal degradation. MBio 7(1): e02184-15.

Bryan, A.M., and Del Poeta, M. 2016. Secretory aspartyl proteinases induce neutrophil chemotaxis in vivo. Virulence 30: 1-3.

Chahales, P., Hoffman, P.S., and Thanassi, D.G. 2016. Nitazoxanide inhibits pilus biogenesis by interfering with folding of the usher protein in the outer membrane. Antimicrobial Agents and Chemotherapy 60(4): 2028-2038.

Chung, L.K., and Bliska, J.B. 2016. Yersinia vs. host immunity: how a pathogen evades or triggers a protective response. Current Opinion in Microbiology 29: 56-62.

Chung, L.K., and Bliska, J.B. 2016. Gut check: IFNg delays mucosal recovery during antibiotic therapy. Cell Host Microbe 20(2): 128 - 129.

Chung, L.K., Park, Y.H., Zheng, Y., Brodsky, I.E., Hearing, P., Kastner, D.L., Chae, J.J., and Bliska, J.B. 2016. The Yersinia virulence factor YopM hijacks host kinases to inhibit type III effector-triggered activation of the pyrin inflammason. Cell Host Microbe doi: 10.1016/j.chom.2016.07.018.

Cieniewicz, B., Santana, A.L., Minkah, N., and Krug, L.T. 2016. Interplay of murine gammaherpesvirus 68 with NF-kappaB signaling of the host. Frontiers in Microbiology 7: 1202.

Cieniewicz, B., Santana, A.L., Minkah, N., and Krug, L.T. 2016. Interplay of murine gammaherpesvirus 68 with NF-kappaB signaling of the host. Frontiers in Microbiology 7: 1202.

Espaillat, M.P., Kew, R.R., and Obeid, L. (2017). Sphinogolipids in neutrophil function and inflammatory responses: mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. Advances in Biological Regulation 63: 140-155.

Fan, G., Zhang, S., Gao, Y., Greer, P.A., and Tonks, N.K. 2016. HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer. Genes and Development 30(13): 1542-1557.

Ivanova, E., and Carpino, N. 2016. Negative regulation of TCR signaling by ubiquitination of Zap-70 Lys-217. Molecular Immunology 73: 19-28.

Li, X., Burton, E.M., and Bhaduri-McIntosh, S. (2017). Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells. PLoS Pathogens 13(3): e1006249.

McLaughlin, P., and van der Velden, A.W. 2016. Salmonella gives MARCH(ing) orders to MHC-II. Cell Host and Microbe 5(9): 551-552.

McLaughlin, P., McClelland, M., Yang, H.-J., Porwolik, S., Bogomolnaya, L., Chen, J.-S., Andrews-Polymenis, H., and van der Velden, A. 2017. Contribution of asparagine catabolism to Salmonella virulence. Infection and Immunity 85(2): e00740-16.

Mukherjee, K., Gardin, J., Futcher, B., and Leatherwood, J. 2016. Relative contributions of the structural and catalytic roles of Rrp6 in exosomal degradation of individual mRNAs. RNA 22(9): 1311-1319.

Naseem, S., Min, K., Spitzer, D., Gardin, J., and Konopka, J.B. (2017). Regulation of hyphal growth and N-acetylglucosamine catabolism by two transcription factors in Candida albicans. Genetics, in press.

Nomakuchi, T.T., Rigo, R., Aznarez, I., and Krainer, A.R. 2016. Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay. Nature Biotechnology 34(2): 164-166.

Ostapchuk, P., Suomalainen, M., Zheng, Y., Boucke, K., Greber, U.F., and Hearing, P. (2107). The adenovirus major core protein VII is dispensable for virion assembly but is essential for lytic infection. PLoS Pathogens 13(6): e1006455.

Parashar, K., Kopping, E., Frank, D., Sampath, V., Thanassi, D.G., and Carpino, N. (2017). Increased resistance to intradermal Francisella tularensis LVS infection by inactivation of the Sts phosphatases. Infection and Immunity, in press.

Parrino, S.M., Si, H., Naseem, S., Groudan, K., Gardin, J., and Konopka, J.B. (2017). camp-independent signal pathways stimulate hyphal morphogenesis in Candida albicans. Molecular Microbiology 103(5): 764-779.

Pham, T., Henderson, N.S., Werneburg, G.T., Thanassi, D.G., and Delcour, A.H. 2016. Electrostatic networks control plug stabilization in the PapC usher. Molecular Membrane Biology 16: 1-10.

Pham, T., Werneburg, G.T., Henderson, N.S., Thanassi, D.G., and Delcour, A.H. 2016. Effect of chaperone-adhesin complex on plug release by the PapC usher. FEBS Letters 590(14): 2172-2190.

Rubin, E., Werneburg, G.T., Pales Espinosa, E., Thanassi, D.G., and Alsam, B. 2016. Identification and characterization of peptidases secreted by quahog parasite unknown (QPX), the protistan parasite of hard clams. Diseases of Aquatic Organisms 122(1): 21-33.

Santana, A.L., Oldenburg, D.G., Kirillov, V., Malik, L., Dong, Q., Sinayev, R., Marcu, K.B., White, D.W., and Krug, L.T. (2017) RTA occupancy of the origin of lytic replication during murine gammaherpesvirs 68 reactivation from B cell latency. Pathogens 6(1): e9.

Sarowar, S., Hu, J., Werneburg, G.T., Thanassi, D.G., and Li, H. 2016. The Escherichia coli P and type 1 pilus assembly chaperones PapD and FimC are monomeric in solution. Journal of Bacteriology 198(17): 2360-2390.

Schoberle, T.J., Chung, L.K., McPhee, J.B., Bogin, B., and Bliska, J.B. 2016. Uncovering an important role for YopJ in the inhibition of caspase-1 in activated macrophages and promoting Yersinia pseudotuberculosis virulence. Infection and Immunity 84(4): 1062-1072.

Torres, A., Luke, J.D., Kullas, A.L., Kapilashrami, K., Botbol, Y., Koller, A., Tonge, P.J., Chen, E.I., Macian, F., and van der Velden, A.W. 2016. Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming. Journal of Leukocyte Biology 99(2): 387-398.

Zheng, Y., Stamminger, T., and Hearing, P. 2016. E2F/Rb family proteins mediate interferon-induced repression of adenovirus immediate early transcription to promote persistent viral infection. PLoS Pathogens 12(1): e1005415.


Abstracts, Conferences/Colloquiums, Invited Talks, Presentations

Bridges, R.G., Sohn, S.-Y., Wright, J., Leppard, K.N., and Hearing, P. The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of the General Transcription Factor TFII-I to Direct Proteasomal Degradation. DNA Tumor Virus Meeting 2016. July 18-23, Montreal, Canada.

Burton, E., Koganti, S., Li, X., and Bhaduri-McIntosh, S. Kruppel-associated Box (KRAB)-associated protein (KAP)-1 is Repressed and Post-translationally Modified Early During Epstein-Barr virus Lytic Cycle. 17th International Symposium on Epstein-Barr Virus and Associated Diseases. August 8-12, 2016, Zurich, Switzerland.

Burton, E., Koganti, S., and Bhaduri-McIntosh, S. Novel Observations on KAP1/TRIM28 in the context of the Epstein-Barr Virus Lytic Cycle. 17th University of Pennsylvania Herpesvirus Symposium. June 23, 2017.

Chung, L. Infection by Injection: How Pathogenic Yersinia Activate and Subvert Immune Responses. Provost’s Graduate Student Lecture Series. March 24, 2016, Stony Brook, NY.

Espaillat, M.P. The Lipids in Your Gut: Defining the Role of Sphingolipids in Inflammatory Bowel Disease. Research Café Series, Center for Inclusive Education. March 21, 2016. Stony Brook, NY.

Fan, G., Bonham, C., Zhang, S., Haque, A., and Tonks, N.K. Interplay between PARP1 and PTP1B Modulates Signaling in Insulin-Resistant HepG2 Cells. The PARP Family and ADP-Ribosylation. April 13-16, 2016. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Kopping, E.J., and Thanassi, D.B. TolC-Dependent Modulation of Host Cell Death by F. novicida. Gordon Research Conference on Microbial Toxins and Pathogenicity. July 10-15, 2016. Waterville Valley, NH.

Medici, N., Chung, L.K., Chae, J.J., and Bliska, J.B.  Studies of Yersinia Effector-triggered Pyrin Inflammasome Activation in Macrophages. ASM Microbe, June 1 - 5, New Orleans, LA.

Minkah, N.K.*,Van Skike, N.*, Wu, G., Benziger, P.T., Kara, M., Tibbetts, S.A., Kim-Holzapfel, D., French, J.B., Oldenburg, D.G., White, D.W., and Krug, L.T. Absence of ORF75A, a Member of the Gammaherpesvirus FGARAT Family, Reduces the Specific Infectivity of MHV68 Particles and Impairs Acute Replication and Reactivation from Latency in the Host. 17th University of Pennsylvania Herpesvirus Symposium. June 23, 2017. *Equal contribution.

Minkah, N.K.*,Van Skike, N.*, Wu, G., Benziger, P.T., Kara, M., Tibbetts, S.A., Kim-Holzapfel, D., French, J.B., Oldenburg, D.G., White, D.W., and Krug, L.T. Absence of the Viral FGARAT ORF75A Reduces the Specific Infectivity of Particles and Impairs Replication and Dissemination of Murine Gammaherpesvirus in vivo. 36th Annual Meeting of the American Society for Virology, June 24-28, 2017. *Equal contribution.

Motley, M.P., Diago-Navarro, E., Yu, W., Ruiz-Perez, G., Chikhalya, A.Y., and Fries, B.C. Characterizating Monoclonal Antibodies Generated Against the Capsular Polysaccharide of ST258 Carbapenem-Resistant Klebsiella pneumoniae. June 1-5, 2017. ASM Microbe, New Orleans, LA.

Werneberg, G. Dissection of Usher-Chaperone-Subunit Interactions during Pilus Biogenesis in Escherichia coli. Provost’s Graduate Student Lecture Series. March 24, 2016, Stony Brook, NY.

Zhang, S., Hao, Y., Hammell, M., Wilkinson, J.E., and Tonks, N.K. A Functional Study in Animal Models Identifies PTPN23 as a Tumor Suppressor in Breast Tumorigenesis through Modulation of FYN Activity. 81st Cold Spring Harbor Laboratory Symposium on Quantitative Biology. June 1-5, 2016. Cold Spring Harbor, NY.


Post-doctorates Obtained and Professional Appointments

Espaillat, M.P. (2017). Postdoctoral fellow, Translational Research - Oncology, Janssen Pharmaceutical Companies, Philadelphia, PA.

Gardin, J. (2016). Postdoctoral fellow, Jackson Laboratory, Bar Harbor, ME.

Ivanova, E. (2016). Postdoctoral fellow, Department of Pathology, New York University, New York, NY.

McLaughlin, P. (2016). Postdoctoral fellow, St. Georges University School of Veterinary Medicine and Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY.