Ph.D. Johns Hopkins University
Phone: (631) 632-9877 - office
Fax: (631) 632-6661
Life Sciences Building
Office: Room 540
Lab: Room 565
Qiaojie Xiong received undergraduate degree in biological science from University of Science and Technology of China. She then attended the Johns Hopkins University, school of medicine, where she received Ph.D. in Physiology. She was a postdoctoral fellow in Cold Spring Harbor Laboratory from 2008 to 2015. She joined the faculty of the Department of Neurobiology & Behavior at Stony Brook University in 2015.
How do we learn new skills, and how do we store memories? Since Richard Semon brought us the term of ‘memory engram’ about a century ago, numerous animal and computational models, behavioral paradigms, and experimental techniques have been developed to trace the memory formation and storage in the brain. Accumulating evidence has suggested that behavioral learning may induce specific changes in neuronal excitability, activity and/or connectivity in certain brain regions and neuronal populations, which could serve as a potential locus for memory engram. However, a comprehensive unit encoding sufficient and causal information for memory engram and the mechanisms underlying it remains absolutely elusive.
In my laboratory, we use rodent models to explore the neural pathways, neuronal ensembles, and synaptic activity/plasticity that underlying memory formation and storage/retrieval mechanisms. Rodent behavior training, in vivo tetrode recording, in vivo imaging, slice recording, optogenetics and immunohistochemistry are used in these studies.
- Laboratory Personnel
- Xiong Q, Znamenskiy P, Zador AM. Corticostriatal plasticity underlying acquisition of an auditory discrimination task. Nature 521(7552):348-51 (2015)
- Xiong Q, Oviedo HV, Trotman LC, Zador AM. PTEN regulation of local and long-range connections in mouse auditory cortex. J Neurosci. 32(5):1643-52. (2012)
- Xiong Q, Sun H, Zhang Y-M, Nan F-J, Li M. Combinatorial augmentation of voltage-gated KCNQ potassium channels by chemical openers. Proc Natl Acad Sci U S A. 105(8):3128-33 (2008)
- Xiong Q, Gao Z, Wang W, Li M. Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds. Trends Pharm Sci. 29(2): 99-107. (2008)
- Xiong Q, Sun H, Li M. Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 3(5):287-96. (2007)