PhD, University of Pennsylvania
Office: (631) 632-9178
Life Sciences Building
Office: Room 534
Lab: Room 525
The goal of the research in my laboratory is to understand the relationship between intrinsic properties of individual neurons and nervous system function. We are particularly interested in motor function and in the plasticity of motoneuron electrical properties induced by neuronal activity, neurotransmitters, hormones, growth factors and injury. To this end, we utilize electrophysiological techniques to examine motoneuron properties and function in rats and mice.
A major focus is the neural control of micturition and injury-induced bladder-sphincter dyssynergia. Frequently a consequence of injury to the spinal cord, bladder-sphincter dyssynergia is due in large part to hyperactivity of the external urethral sphincter muscle such that it fails to relax during bladder contraction resulting in incomplete voiding and urine retention. Ongoing studies address the hypothesis that spinal cord injury produces an increase in the intrinsic excitability of external urethral sphincter motoneurons that contributes significantly to the development of bladder-sphincter dyssynergia.
- Laboratory Personnel
- D'Amico S. C. and Collins, W.F., III (2012) External urethral sphincter motor unit recruitment patterns during micturition in the spinally intact and transected rat. J. Neurophysiol. 108:2554-2567.
- D'Amico S. C., Schuster, I. P. and Collins, W.F., III (2011) Quantification of external urethral sphincter and bladder activity during micturition in the intact and spinally transected adult rat. Exp. Neurol. 228(1):59-68.
- Peshori, K.R., Collins, W.F., III and Mendell, L.M. (1998) EPSP amplitude modulation at the rat Ia-alpha motoneuron synapse: Effects of GABA-B receptor agonists and antagonists. J. Neurophysiol. 79:181-189.
- Gonzalez, M and Collins, W.F., III (1997) Retrograde regulation of motoneuron excitability by brain-derived neurotrophic factor. J. Neurophysiol. 77:502-506.
- PubMed Linked Publications