Department of Biomedical Engineering
PhD, Columbia University
Phone: (631) 632-1008
Stony Brook University
The Laboratory for Computational Neurodiagnostics performs clinical research on the neurobiology of emotional arousal, and its effects on physiology and cognition.The Laboratory for Computational Neurodiagnostics studies provide simultaneous measurement of neural, cardiac, endocrine, cognitive, immune, epigenetic and clinical components of the human emotional response. These data are then analyzed using statistics, system identification, and complex systems analyses adapted from control systems engineering, to develop data-driven modeling and simulations with wide-ranging applications. The Laboratory for Computational Neurodiagnostics performs integrative multi-disciplinary research on areas as diverse as: the neurobiological etiology, diagnosis, and treatment of schizophrenia and other mental illnesses; factors responsible for and predictive of individual variability among healthy individuals in their vulnerability and resilience to chronic and acute high-stress environments; the impact of high-stress environments on cognitive processing, pre-attentive sensorimotor gating, and strategic decision-making; functional and anatomical connectivity in fMRI , EEG, and near-infrared spectroscopy (NIRS), and the biochemistry/physiological effects of human alarm pheromones. LSEC develops computational tools for innovative systems-based analyses of fMRI and NIRS, as well as MR-compatible instrumentation that complements our approach.
- Laboratory Personnel
- Dikecligil GN, Mujica-Parodi LR (in press): Ambulatory and Challenge-Associated Heart Rate Variability Measures Predict Cardiac Responses to 'Real-World' Acute Emotional Stress. Biological Psychiatry.
- Tolkunov D, Rubin D, Mujica-Parodi LR (2010): Power spectrum scale invariance quantifies limbic dysregulation in trait anxious adults using fMRI: adapting methods optimized for characterizing autonomic dysregulation to neural dynamic time series. Neuroimage. 50:72-80.
- Mujica-Parodi LR, Strey HH, Frederick B, Savoy R, Cox D, Botanov Y, Weber J (2009): Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS ONE. 4:e6415.
- Mujica-Parodi LR, Renelique R, Taylor MK (2009): Higher body fat percentage is associated with increased cortisol reactivity and impaired cognitive resilience in response to acute emotional stress. Int J Obes (Lond). 33:157-165.
- Mujica-Parodi LR, Korgaonkar M, Ravindranath B, Greenberg T, Tomasi D, Wagshul M, et al. (2009): Limbic dysregulation is associated with lowered heart rate variability and increased trait anxiety in healthy adults. Hum Brain Mapp. 30:47-58.
- Mujica-Parodi LR, Yeragani V, Malaspina D (2005): Nonlinear complexity and spectral analyses of heart rate variability in medicated and unmedicated patients with schizophrenia. Neuropsychobiology. 51:10-15.