Richard R. Kew, PhD 
Associate Professor of Pathology
Basic Science Tower, Level 9
Stony Brook Medicine
Stony Brook, NY 11794-8691
Tel: (631) 444-3941
Fax: (631) 444-3424
Email: Richard.Kew@stonybrookmedicine.edu
Research Summary:
Dr. Kew’s lab is interested in how components of the innate immune system contribute to the pathology of tissue injury. A major focus is to determine how plasma and cell-derived cofactors regulate chemotactic signals that direct leukocytes from the blood to sites of inflammation. Several experimental approaches (biochemical, cellular, molecular and proteomic) are being utilized to investigate the mechanisms by which a ubiquitous albumin-like plasma protein, the vitamin D binding protein (DBP), regulates leukocyte migration to activated complement peptide C5a. Aberrant and/or excessive activation of complement, with subsequent generation of C5a, has been strongly associated with the pathogenesis of several inflammatory disorders. C5a is one of the most potent and physiologically important chemotactic factors. Understanding how this activity is regulated will have major physiological significance and may facilitate the design of therapeutics that can modulate excessive tissue recruitment of leukocytes from the blood.
| Education: | ||||
| Institution and Location | Degree | Year(s) | Field of Study | |
| University of Massachusetts at Lowel, MA | B.S. | 1979 | Biological Sciences | |
| University of Massachusetts at Lowell, MA |
M.S. | 1981 | Biochemistry | |
| Stony Brook University, NY | Ph.D | 1986 | Cellular & Molecular Pathology | |
Positions and Employment: |
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| 1986-88 | Postdoctoral Fellow, St. Louis University |
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| 1989-90 | Research Fellow, Graduate Hospital and the University of Pennsylvania |
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| 1990-09 | Assistant Professor of Pathology, Stony Brook University |
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| 1990-92 | Graduate Program Faculty in Cell & Molecular Pathology | |||
| 1992-present | Graduate Program Faculty in Molecular & Cellular Biology | |||
| 2001-present | Graduate Program Faculty in Molecular Genetics & Microbiology | |||
| 2003-present | Departmental Radiation Safety Officer | |||
| 2006-10 | Member, University Radiation Protection Committee | |||
| 2009-present | Chair, University Laboratory Safety Council | |||
| 2009-present | Senator, School of Medicine Faculty Senate | |||
| 2010-present | Associate Professor of Pathology, Stony Brook University |
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Other Experience and Professional Memberships (selected): |
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| 1991-present | Society for Leukocyte Biology | |||
| 1994-present | American Association of Immunologists | |||
| 2005-present | International Complement Society | |||
| 2010 | Local Organizing Committee for the XXIII International Complement Workshop | |||
| 2010 | Awards Committee for the International Complement Society | |||
Honors (selected): |
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| 1979 | Biological Sciences Senior Research Award, University of Massachusetts at Lowell | |||
| 1989 | Recipient of a Hulda and George McKay Research Fellowship | |||
| 1991 | Young Investigator Award from the Society for Leukocyte Biology | |||
| 2000 | Leadership Award from the Heart Council of Long Island | |||
| 2005 | Promising Inventor Award from Research Foundation of SUNY | |||
| 2007 | Mentor Award from the University of Texas Medical School at Houston | |||
| 2009 | Awarded U.S. patent number 7,547,676 entitled “Antagonist Peptides to the C5a Chemotactic Function of the Vitamin D Binding Protein” |
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| 2010 | Inventor Award from the Town of Brookhaven, NY | |||
Peer Reviewed Publications:
