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Jingfang Ju, PhD
Associate Professor
Co-director of Translational Research Laboratory
Basic Science Tower, Level 9 Rm 185
Stony Brook Medicine
Stony Brook, NY 11794-8691

Tel:  (631) 444-3598
Fax: (631) 444-3424
E-mail: jingfang.ju@stonybrookmedicine.edu

Research Interests:

Dr. Ju’s research at Stony Brook University School of Medicine focuses on elucidating the mechanism of translational control mediated by non-coding RNAs in cancer and translating the new discovery to clinical cancer diagnosis and therapy.

His group is the first to discover that p53 regulates the expression of certain miRNAs, opening a new frontier in cancer research.

Dr. Ju’s group is actively investigating the mechanism of miRNAs in proliferation, cell cycle control, chemoresistance to fluoropyrimidines and antifolates in tumor stem cells, and epithelial-to-mesenchymal transition. His group is also developing novel approaches to study post-transcriptional control mediated by miRNAs and RNA binding proteins. As for the translational research, they are interested in the investigation of miRNAs as biomarkers in cancer diagnosis and prognosis.

Education:   
Institution and Location Degree
Year
Feild of Study
Northeastern UniversityB.S.1989Engineering
University of Southern CaliforniaPh. D.1996Biochem/Molecular Biology
Yale UniversityPost Doc
1999Pharmacology
Positions and Employment: 
1999-2003Senior Research Scientist and Genomic Technology Team Leader, CuraGen Inc., CT
2004-2008Head of the Cancer Genomics, Assistant Professor of Oncological Sciences, Mitchell Cancer Institute
2008-presentCo-Director of Translational Research, Department of Pathology, Stony Brook Medicine
2009-presentGraduate faculty, Molecular and Cellular Biology Program, Stony Brook Medicine
2009-presentGraduate faculty, Genetics Program, Stony Brook Medicine
2013-presentAffiliated faculty of The RNA Institute
Other Experience and Professional Memberships (selected):
2012-presentEditorial Board, microRNA
2012-presentEditorial Board, Biomarker Research
2011-presentReview Editor, Frontiers in Genomics Assay Technology
2007-presentEditorial Board, Canacer Genomics and Protemics
2006Managing Editor, Frontiers in Biosciences
2005-presentMember, American Society of Clinical Oncology
2004-presentNational Cancer Institute Study Section Member (Innovative Molecular Analysis Technology: IMAT, Applied Emerging Technology for Cancer Research, SBIR/STTR, Cancer Biomarker, BMCT, U-01, P-01, K01, R03, K99)
2003-presentMember, Society of Chiniese Bioscientists in America
1993-presentMember, American Association for Cancer Research
Honors (selected):
2012Excellence in Mentoring Graduate and Postdoctoral Fellows Stony Brook Medicine Pathology
2000Stellar Achievement Award, CuraGen Corporation
1999National Research Service Award, NIH
1996Glaxo Welcome Young Clinical Research Scholar Award
1992Scholarship from Los Alamos National Laboratory Science and Alliance Program



Selected Publications:
1.Karaayvaz M, Zhai H, Ju J. miR-129 promotes apoptosis and enhances chemosensitivity to 5-fluorouracil in colorectal cancer. Cell Death Dis. 2013.193. 4: e659; doi:10.1038/cddis.
2.Zhai H, Fesler A, Ju J. MicroRNA – A third dimension in autophagy. Cell Cycle. 2013 12(2): 246-50
3.Zhai H, Song B, Xu X, Zhu W, Ju J. Inhibition of autophagy and tumor growth in colon cancer by miR-502. Oncogene. 2013. 32(12):1570-9.
4.Xu X, Gnatenko D, Ju J, Hitchcock I, Martin D, Zhu W, Bahou W. Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms. Blood. 2012. 120(17):3575-85.
5.Dong P, Karaayvaz M, Kaneuchi M, Jia N, Hamada J, Watari H, Sudo S, Ju J*. Sakuragi N. Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis. Oncogene. 2012. July 20. [Epub ahead of print].
6.Song B, Wang Y, Titmus MA, Botchikina G, Ju J. miR-215 regulates dihydrofolate reductase and thymidylate synthase and increases chemoresistance in osteosarcoma and colon cancer. Mol. Cancer. 2010. 9:192
7.Kudo K, Xi Y, Wang Y, Song B, Chu E, Ju J, Russo J, Ju J. Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip). Nucleic Acids Research, 2010. 38(9):e104.
8.Song B, Wang Y, Xi Y, Kudo K, Bruheim S, Botchkina GI, Gavin E, Wan Y, Formentini A, Kornmann M, Fodstad O, Ju J. Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene. 2009, 28(46):4065-74.
9.Song B, Wang Y, Kudo K, Gavin E, Xi Y, Ju J. miR-192 regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clinical Cancer Research.  2008, 14: 8080-8086.
10.Xi Y*, Nakajima G*, Gavin E, Morris CG, Kudo K, Hayashi K, Ju J. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA. 2007. 13(10):1668-74.
11.Ju J, Schmitz JC, Song B, Kudo K, Chu E. Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. Clinical Cancer Research. 2007. 13(14); 4245-4251.
12.Xi Y, Shalgi R, Fodstad O, Pilpel Y, Ju J. Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer. Clinical Cancer Research. 2006. 12 (7): 2014-2024.

PubMed Publications