normal  medium  large

Richard R. Kew, PhD 
Associate Professor of Pathology
Basic Science Tower, Level 9
Stony Brook Medicine
Stony Brook, NY 11794-8691

Tel: (631) 444-3941
Fax: (631) 444-3424
Email: richard.kew@stonybrookmedicine.edu

Research Summary:
Dr. Kew’s lab is interested in how components of the innate immune system contribute to the pathology of tissue injury. A major focus is to determine how plasma and cell-derived cofactors regulate chemotactic signals that direct leukocytes from the blood to sites of inflammation. Several experimental approaches (biochemical, cellular, molecular and proteomic) are being utilized to investigate the mechanisms by which a ubiquitous albumin-like plasma protein, the vitamin D binding protein (DBP), regulates leukocyte migration to activated complement peptide C5a. Aberrant and/or excessive activation of complement, with subsequent generation of C5a, has been strongly associated with the pathogenesis of several inflammatory disorders. C5a is one of the most potent and physiologically important chemotactic factors. Understanding how this activity is regulated will have major physiological significance and may facilitate the design of therapeutics that can modulate excessive tissue recruitment of leukocytes from the blood.

Education:
Institution and Location Degree Year(s) Field of Study
University of Massachusetts at Lowel, MA B.S.1979Biological Sciences
University of Massachusetts at Lowell, MA
M.S. 1981 Biochemistry
Stony Brook University, NY Ph.D 1986 Cellular & Molecular Pathology

Positions and Employment:
1986-88 Postdoctoral Fellow, St. Louis University
1989-90 Research Fellow, Graduate Hospital and the University of Pennsylvania
1990-09 Assistant Professor of Pathology, Stony Brook University
1990-92 Graduate Program Faculty in Cell & Molecular Pathology
1992-present Graduate Program Faculty in Molecular & Cellular Biology
2001-present Graduate Program Faculty in Molecular Genetics & Microbiology
2003-present Departmental Radiation Safety Officer
2006-10  Member, University Radiation Protection Committee
2009-present  Chair, University Laboratory Safety Council
2009-present  Senator, School of Medicine Faculty Senate
2010-present Associate Professor of Pathology, Stony Brook University

Other Experience and Professional Memberships (selected):
1991-present  Society for Leukocyte Biology
1994-present American Association of Immunologists
2005-present International Complement Society
2010 Local Organizing Committee for the XXIII International Complement Workshop
2010 Awards Committee for the International Complement Society

Honors (selected):
1979 Biological Sciences Senior Research Award, University of Massachusetts at Lowell
1989 Recipient of a Hulda and George McKay Research Fellowship
1991 Young Investigator Award from the Society for Leukocyte Biology
2000 Leadership Award from the Heart Council of Long Island
2005 Promising Inventor Award from Research Foundation of SUNY
2007  Mentor Award from the University of Texas Medical School at Houston
2009 Awarded U.S. patent number 7,547,676 entitled “Antagonist Peptides to the C5a Chemotactic
Function of the Vitamin D Binding Protein”
2010 Inventor Award from the Town of Brookhaven, NY

Peer Reviewed Publications: