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Research Support

Research Support (current)

1R01CA2203667-01 (coPI’s: T. Rosenquist, R. Turesky)
Stony Brook University, University of Minnesota
DNA adductomics of the urinary system
This research program is to establish targeted, data-dependent (DDA) and data-independent acquisition (DIA) methods to screen for DNA adducts in human tissues, focusing on genetoxic chemicals found in the environment, diet, and herbal medicines, and on compound ds produced endogenously. This study will characterize DNA adducts found in renal and urothelial tissues and in exfoliated urinary cells of cancer patients, using DDA and DIA MS scanning methods, and correlate DNA adduct signatures with mutational signatures.
06/20/2017 – 06/30/2022

ES0188092 (PI: R. Turesky)
University of Minnesota, Stony Brook University
New Biomonitoring Methodologies to Measure DNA Adducts in Human Tissue
DNA adducts formed in the urinary bladder by exposure to hazardous chemicals in the environment, medicines, tobacco smoke, diet, or endogenously produced electrophiles will be screened by ion trap mass spectrometry. We will establish a robust assay employing exfoliated urinary cells as a noninvasive biospecimen to screen for DNA adducts. These biomonitoring approaches may help us to identify the major chemicals that damage DNA and contribute to the etiology of bladder cancer.
08/01/2016 – 07/31/2021

Marsha & Henry Laufer Foundation (PI: Grollman)
Stony Brook University
Toxicogenomics of Aristolochic Acid Nephropathy and Associated Cancers
To confirm exposure to Aristolochia herbs for populations in which the signature mutation for aristolochic acid has been detected, and to establish aristolochic acid as a proximate cause of renal cell, hepatocellular and other human cancers worldwide.
09/01/2012 – 08/31/2020

R21 ES028539-01 (PI: Rosenquist)
Stony Brook University
DNA Adduct Genomics
The goal of this project is to immune-purify and sequence genomic DNA fragments containing DNA adducts.
07/01/2017 – 06/31/2019

 

Other Support
The Director gratefully acknowledges generous gifts from Mr. and Mrs. Leo Zickler, Mrs. Arline Lubin, and Drs. Marsha and Henry Laufer.